Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Stopping the meds will return you to your normal self. Physicians who use the drug for COVID now swear by it. Sage Hana. You can use fluoxetine as well (aka Prozac). Proxalutamide and fluvoxamine pushers and the early treatment grift. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. It cant be more clear than this. 90,000 people will die in the next 3 weeks alone if we continue to ignore this drug that has caused no harm. The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). At the beginning of the COVID-19 pandemic, Steve Kirsch created the COVID-19 Early Treatment Fund (CETF) to finance trials of off-patent drugs in an attempt to find a potent treatment that had been staring us in the face. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Fluvoxamine is an inexpensive drug that has been in use for 37 years and has been used by an estimated 10 million people. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? We now have a viable solution to reduce COVID hospitalization and mortality; Say you just got diagnosed with COVID. One is to reduce the threat of nuclear war. Dosage there is 30mg once a day. Here are the key things you should know about fluvoxamine for COVID: It works. Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. . Fluvoxamine was reportedly added to just 2 practice guidelines (. That study was featured on 60 Minutes. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. Doctors have no excuse for not prescribing. With little government funding available for such work, Kirsch founded the Covid-19 Early Treatment Fund (CETF), putting in $1 million of his own money and bringing in donations from Silicon Valley luminaries: the CETF website lists the foundations of Marc Benioff and Elon Musk as donors. Soon after his appearance on the DarkHorse podcast, several partners of his most recent startup, M10, expressed concerns about the increasing extremism of Kirschs vaccine views. If you have trouble getting a prescription, perhaps you have OCD? NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. Los Altos Hills resident Steve Kirsch funded research into the drug fluvoxamine as a treatment for COVID-19. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! Dosage there is 30mg once a day. Still, in the moment, his question threw me, and I stuttered. . Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. In fact, he was unwittingly the source for one of Kirschs figures. of the 'intellectual dark web '" and allowed him to access a "large and receptive audience to his claims about a fluvoxamine conspiracy". We dont want to feed the anti-vaccine trolls, so we actively suppress clear scientific data. 12:45 AM . All the supporting observational studies were positive as well. It never was. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. Avoid caffeine, benadryl, tylenol, and alcohol. 36m "We found Fauci was the most highly compensated federal employee. Paper reviewing the evidence and mechanisms of action for fluvoxamine: Lenze Phase 2 RCT published Nov 12, 2020: Seftel RWE trial that confirmed the Phase 2 trial published Feb 1, 2021. Nov 12: Steve Kirsch gives talk on CETF to HarvardBusiness School hosted by Dr. Seftel Nov 13:Mass COVID outbreak at GGF is now publiclyknown Nov 16: Seftel, the track physician at GGF, startsFLV . I have all of these on hand and I load up on vitamin D3 every day. The medical community doesnt care about saving lives. Early research suggests that fluvoxamine, an FDA approved medication for depression and obsessive compulsive disorder, can be an effective early treatment for COVID-19. The evidence is solid. Dr. Joe Ladapo wrote a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients." This 1/6 of the dose the FDA has approved for OCD (the labelled indication for fluvoxamine)! Vitamin D, NAC, betadine, aspirin, and Nigella sativa are all super cheap, effective, and available without a prescription. Seftel used a 50mg BID dosing for 14 days which was one third of the max dose used in the Lenze study. The claim that the spike is toxic, that came directly from the [DarkHorse episode]. At the dosing for COVID (50mg BID x 14 days), there is a 1% chance of mild-nausea and because the dose is so low and the time it is taken is so short, and there are no psychotropic effects (which require more than 3 weeks of use; the psychotropic effects non-existent if you don't have depression or an anxiety disorder in the first place). The track management was so impressed, they asked for prescriptions. His foundation shifted focus to one goalcuring Steve Kirschby supporting one of the few scientists looking at the disease. , a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. Boulwares trial was part of a wider movement to bulk up the evidence base underlying standard covid treatments, and one of several trials that found no benefit to using hydroxychloroquine. Now weve lost the high ground, Morris told me. And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? No one has been able to come up with an example where phase 2 + this level of evidence resulted in a failure of Phase 3. Silence from the medical community. But thats not a surprise, according to researchers who conducted them: the vast majority of trials for any drug end in failure. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls, she said. But I know something else that few other people know, thanks to a source at the NIH: the NIH was planning to approve fluvoxamine months ago, but they got a call from the FDA telling them not to. They were giving covid patients the antidepressant fluvoxamine as soon as possible after diagnosis, based on anecdotes about the drug limiting the runaway immune response that causes many severe symptoms. The sooner you start, the better the outcomes. The US government accused Janssen of improperly promoting the antipsychotic drug Risperdal to dementia patients despite the drug increasing deaths in the elderly. Thats pretty typical, but your mileage may vary. In California, Silicon Valley tech entrepreneur Steve Kirsch was also thinking about the pandemic. See more below. Fluvoxamine - The backstory T he i nsi de st ory behi nd how f l uvoxami ne became a CO V I D t herapy By Steve Kirsch Last updated: June 3, 2021 . This is the gold standard of evidence based medicine. No long haul symptoms if you start the drug ASAP after first symptoms. And FrameMaker is still a niche product. His efforts became more focused on medical research when, in 2007, he was diagnosed with a rare blood cancer. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. Fluvoxamine has at least a 30% hospitalization and death benefit. The reason is pure corruption. [https://www.quora.com/What-is-the-current-treatment-for-Covid-19/answer/, The most urgent need in the country right now is to reduce. ). During our first conversation, which turned into a multi-hour Zoom session, Kirsch paced through the rooms of his cavernous house with his phone held at chest level, rarely looking down at the camera. Items included in the Television News search service. Most doctors wont use it until NIH greenlights it, no matter what the science says. Enter the email address you signed up with and we'll email you a reset link. Fluvoxamine has a systematic review and meta-analysis published in a top medical journal. Its whether Merck can make a killing that matters. In September, he resigned as CEO and gave up his board seat. Medium banned him for misinformation. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. And he wont talk to you either if you ask nosy questions like Cliff, my risk benefit analysis shows you should be rushing to recommend this drug. [4] Steve Kirsch - Silicon Valley Philanthropist Shares Review of CDC Data: COVID-19 Vaccine Associated with 100X Deaths Compared to Influenzas [5] Steve Kirsch - FOIA Document for Vaccine Discussion as to mRNA-based Vaccine Safety Signals Added 12th August 2021: Reason is the hospital gets release from liability if they follow NIH guidelines. Over the summer, the conflict reached his most recent startup, M10. He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. He applied the drug to a large COVID outbreak at Golden Gate Fields just days after the Lenze trial was published. Some countries dont have fluvoxamine so this is the alternative. Zero. We should be making decisions now based on the evidence on the table today. So far, doctors have failed to share his sense of urgency. When I asked him why so many experts in the field disagreed with him, he alleged there were effortseither malicious or negligentto suppress evidence of cheap, effective covid treatments. If not, they should at least acknowledge that fluvoxamine might be helpful by at least listing it as a possibility. Added to FLCCC protocols and Fareed-Tyson protocol among others. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. In the second trial, it was shown to be 100% effective in long-haul COVID symptoms: None of the treated patients had any long-haul symptoms after 2 weeks compared to 60% of untreated patients having 1 or more of the 15 long-haul symptoms after two weeks, and 29% having 4 of more of the long haul symptoms after 2 weeks. The ongoing battle between social-media companies and covid-19 misinformation pushersincluding US president Donald Trumpstepped up again this week thanks to a new viral video. It has enrolled only 130 people in the first month and is enrolling only 70 per week now. With cases spiking, the Los Angeles area banned gatherings. This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). Drug interactions should be checked for. Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. He thinks # killed by vax could be anywhere between 0 and 150K people dead.. The differences are obvious to untrained eyes. Hes spending his own money to do what he thinks is right. The trials that were abandoned for futility werent getting events because the patients were given standard of care meds. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. Do they sell it anywhere? It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for, because they were rejected by 10 journals. Most recent articles first. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. Instead, the government prefers to fund and promote new, proprietary drugs and vaccines, he says. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. Some countries dont have fluvoxamine so this is the alternative. . It is perhaps the greatest unnecessary loss of life in American history. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. This post was written to memorialize the corruption. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. Im just telling you the truth. If you cant get a prescription for COVID, then perhaps you have OCD? The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. The documents in the data room discuss all eight (you'll need access to the restricted area to see the presentation on all 8). Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. 19 In addition, several . Can I see your risk-benefit analysis?. He was recently featured on 60 Minutes which highlighted his . Perhaps Kirschs most effective tactic, though, is simply his willingness to outlast everyone else. But not 150K. Comparison with molnupiravir. On January 22, 2021, thirty key opinion leaders (KOL) from NIH, CDC, and leading academic institutions met to review the evidence for using fluvoxamine for treating COVID. This site requires JavaScript to run correctly. It works best when it is given early, as soon as symptoms start. And not zero., Kirsch immediately forwarded the exchange to me and, I suspect, other journalists. The 5 observational studies is icing on the cake. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Thats why they didnt even fund the fluvoxamine trial, he told me. No more. One user reported dilated pupils and increased heart rate (which could be nerves about the dilated pupils). Steve Kirsch is looking for an explanation for 171,000 excess deaths. Early treatment with existing drugs is the fastest, most effective, and lowest. We need to keep people out of the hospital in the first place. . Both drugs have compelling data that is hard to explain if the drug doesn't work. S1R can essentially turn off IRE1, so IRE1 will not activate XBP1, so that the cytokine production will decrease. Summary of key evidence. They immediately ruled out the vaccine, because the vaccine is, quote, safe.. By March 2020, hed settled on the idea of searching for covid treatments in the pre-existing pharmacopeia. That was a lie. He has a history of giving away some of his millions to good causes, and when COVID-19 began. I must admit that this is an anniversary that snuck are all super cheap, effective, and available without a prescription. For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. . Hes a genuinely good guy. We look for advances that will have a big impact on our lives and break down why they matter. The agency quickly slapped down the comments from Kirsch, a tech mogul with a fortune once estimated at $230 million, even as the claims triggered a flurry of false social-media posts attributing. The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. That was a big mistake because the original paper contained text related to earlier studies and the editors chopped it out. In 2013, Johnson & Johnson paid $2.2 billion for its own kickback and fraud scandal, including a specific $400 million fine for its subsidiary Janssen, which manufactures the covid vaccine. has tons of info on fluvoxamine with all the links. Timing is everything with respect to outcomes. Don't underestimate the virus. At that dose, no side effects were reported for his patients (I know of only one person who had mild nausea at that dose) and everyone reversed out their symptoms in an average of 3 days. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. Its all about NIH saying it is OK. Medicine today is driven by government opinion, not science. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. . Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. Medicine today isnt about saving your life. See this. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. 1:49 People are dying. About 10 minutes on the internet will show you those two gentlemen, who have appeared together, have been extensively fact checked for false or misleading claims or misuse of VAERS reporting and other data. He is the inventor of the optical mouse and one of the first Internet search engines, Infoseek. I wanted to get the article out before my flight left. The ICER independent review showed fluvoxamine is more effective than Molnupiravir: Read this article I wrote about using fluvoxamine correctly for COVID. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. Today, we are letting people drown and we are not even telling them there is a life preserver they can ask for today with compelling evidence that is under consideration by the life preserver safety group. Im sorry to sound so cynical. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. The rest of the board soon followed. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. Telling the truth, he tweeted. It is very safe: There is no evidence fluvoxamine is harmful and led to a worse outcome. Refresh. Fluvoxamine public data repository: The fluvoxamine public repository has all the documents related to fluvoxamine for COVID, including the RCT, RWE, observational studies and a link to the 1 hour lecture on serotonin and fluvoxamine. At the end of May this year, Siliciano emailed the other advisors to say that Kirsch had gone off the deep end and he was cutting ties. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. The FDA approved Molnupiravir which was less effective. It does not matter how many lives will be saved. P-value was 10^-14 on that study (done by Dr. There were IRB rules that required the 65 patients to be listed in the diagrams and charts. Elsewhere he has said he began questioning vaccine safety after an unnamed Twitter follower told him several family members died after getting their shots. Here is the latest version. Summarizes the 5 observational studies, RCT, RWE, and some of the more interesting anecdotal data. That was a lie. Completely avoid caffeine, alcohol, tylenol, and benadryl. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. The babys brain was split in half, and it was just covered with blood. This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). Note that some of these articles are inaccurate. Another CETF grant, though, yielded far more exciting results. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. The web value rate of skirsch.io is 2 . . If you cant lay off the java, then try fluoxetine (Prozac). Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. Fluoxetine is just as effective. He started 7 high tech companies, two with billion dollar market caps. reach out to us at It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. What's even worse is that a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die. In the studies and the anecdotes I am aware of, everyone reversed symptoms within days of getting the drug. Online Status. He retired at the largest pension in federal history. When was the last time you saw a phase 3 fail where there was a 100% effect size in both an RCT and RWE study along with 4 independent observational trials all showing a positive effect, and there is clear mechanism of action where there is less than a 1% chance that it is not working (the SSRI's ordered their impact based on their Sigma activation which is 1 in 120 options), and where in every single case we are aware of the patient taking the drug reversed to normal in an average of 3 days? But fear of trying something new prevents any doctor from giving this drug a try. They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. Have the drug on hand. . Adverse reactions/side effects. No more. Timing is everything with respect to outcomes. It was not compatible with his position as CEO to continue taking a very public stance on the vaccines, Richard Char, M10s general counsel, told me. I fixed the link to the fluvoxamine article. Ive used it personally at 50mg twice a day and experience no adverse events at all. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. So much for evidence-based medicine. Steven Todd Kirsch is an American entrepreneur. Over the last 18 months, the fund has granted at least $4.5 million to researchers testing the covid-fighting powers of drugs that are already FDA-approved for other diseases. He prefers iconoclastic approaches, whether by directly funding asteroid detection or advocating for nuclear power to combat global warming. I will . But the potential upsides. Fluvoxamine, created 37 years ago, is an inexpensive and widely available generic drug. What has alarmed many of the scientists associated with CETF, though, are Kirschs reactions to the work hes fundedboth successes and failures. Proven in clinical use all over the world. We didnt come up with better mouse technology than Microsoft did. If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? upcoming events, and more. MD, MPH; Steven C. Marcus, PhD. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. I couldnt tell I was on the drug. 1. You will be wired for 24 hours if you dont heed my advice. After several failed attempts to stop the progression of his disease, he designed his own protocol for chemotherapy and doctor-shopped to find an oncologist who would give it to him. Worst case, if we ignore all additional evidence so the average is a 60% pass rate. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. Hes now outlived his initial prognosis by several years. Our in-depth reporting reveals whats going on now to prepare you for whats coming next. This should be top news, but the press is ignoring this and attempt to write stories about it are killed by the editors. Or just depression about the vaccine mandates?
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